MTHFR, Methylation, Folic Acid & Folate Testing

EPISODE # 7

MTHFR, Methylation, Folic Acid & Folate Testing - A Clinical Perspective

A Deeper Look into MTHFR, Methylation, and Folate

In this episode of The Histamine Well Podcast, Joanne explores the clinical relevance of the MTHFR gene mutation, highlighting the enzyme’s critical role in converting folate into methylfolate. She explains how methylfolate supports the production of SAMe, a key compound used in the essential biochemical process known as methylation.

Joanne breaks down the methylation pathway, the function of SAMe, and the importance of balanced methylation in detoxification, neurotransmitter production, and immune function. She also sheds light on the limitations of folic acid, the complexities of folate testing, and why having an MTHFR mutation doesn’t automatically mean you need methylfolate or have a methylation issue.

This episode offers practical insights for both practitioners and patients navigating MTHFR gene mutations.

Today we discuss:

MTHFR & its role in folate metabolism
MTHFR, methylfolate and SAMe production
Important roles of methylation in the body
Methylation and genetic expression
Why folic acid is a problem for everyone (not just those with an MTHFR mutation)
Testing for the different types of folate
Why taking methylfolate isn’t necessary for everyone
What to consider if you have an MTHFR gene mutation

Just because you have an MTHFR gene mutation doesn’t mean you need to take methylfolate, and it definitely doesn’t mean you have a methylation issue or that you are inverted under methylating. Methylation is far more complicated than just one gene and one nutrient.

Joanne Kennedy

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