EPISODE # 19

Clinical Insights into PMDD, Severe PMS & the Role of Methylation

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Understanding the Hormonal Rollercoaster

In this episode of The Histamine Well, Joanne dives deep into Premenstrual Dysphoric Disorder (PMDD) and severe PMS — the kind that can leave you feeling anxious, depressed, exhausted, and unlike yourself for half the month.

Joanne shares insights from her clinical practice to explore what’s really going on beneath the surface, including:

  • Hormone imbalances like estrogen dominance and low progesterone
  • Inflammation, oxidative stress, and their impact on ovulation
  • Nutrient deficiencies that affect mood and hormone function
  • The surprising role of methylation imbalances — particularly overmethylation — and how this biochemical pathway can disrupt neurotransmitters and mood

 

She also introduces the concept of testing methylation in real time, and shares a powerful patient story that shows how personalized treatment can dramatically improve mood and cycle symptoms.

Whether you’ve been diagnosed with PMDD or you just know your PMS isn’t normal, this episode offers a fresh perspective and hope for more stable cycles and moods.

What You’ll Learn:

  • How cycle irregularity affects mood and hormone balance
  • Signs and symptoms of estrogen dominance and low progesterone
  • Why inflammation and oxidative stress impact ovulation and hormone production
  • The clinical relevance of overmethylation in PMDD
  • How real-time methylation testing is changing treatment approaches
  • Nutrients and strategies Joanne uses in clinical practice to rebalance mood and hormones

Stay well,

Joanne Kennedy

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