EPISODE # 35

Understanding MARCoNS and Its Impact on Inflammation, Histamine, and Chronic Symptoms

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How Nasal Bacterial Colonisation Drives Chronic Inflammation and Histamine Symptoms

In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms.

Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protective biofilms. She explores the connection between MARCoNS and symptoms such as fatigue, brain fog, migraines, anxiety, poor detoxification, and heightened inflammatory responses, especially in individuals who don’t improve despite targeted gut or histamine protocols.

This episode walks listeners through how MARCoNS are identified, with a focus on nasal swab testing, and outlines evidence-informed treatment strategies, including biofilm disruptors, targeted herbal antimicrobials, and supportive therapies designed to reduce bacterial load and calm immune activation.

Whether you’re a health practitioner working with complex chronic cases or an individual struggling with ongoing symptoms that don’t fully resolve, this episode provides practical insight into MARCoNS as a hidden driver of inflammation and histamine dysregulation.

What you’ll learn in this episode:

  • What MARCoNS are and how they impact the immune system
  • Why MARCoNS are linked to chronic inflammation and histamine-related symptoms
  • Common signs and symptoms associated with MARCoNS colonization
  • How nasal swab testing is used to identify MARCoNS
  • Treatment approaches including biofilm disruptors and targeted antimicrobials

Stay well,

Joanne Kennedy

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