In this episode of the Histamine Well Podcast, Joanne explores the complex relationship between high homocysteine, histamine intolerance, methylation, and nutrient metabolism. 

Elevated homocysteine is a significant marker linked to cardiovascular disease, cognitive decline, inflammation, pregnancy complications, and neurological health concerns.

Learn what homocysteine is, why optimal levels matter, and how the methylation cycle works in the body. This episode explains how nutrients such as methylfolate, methyl B12, vitamin B6, and trimethylglycine support homocysteine metabolism — and why many people struggle to tolerate methylated supplements despite needing them.

Joanne also discusses the clinical connection between histamine overload, genetics like the MTHFR gene mutation and COMT enzyme activity, plus how methylation imbalances may contribute to anxiety, insomnia, headaches, skin flare-ups, digestive symptoms, and histamine reactions.

Whether you are a practitioner, student, or someone navigating histamine intolerance, methylation issues, or unexplained reactions to supplements, this episode provides practical insights into understanding the root causes behind elevated homocysteine and improving tolerance to targeted nutrients.