In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, and gut dysfunction.

This case follows a 37-year-old woman experiencing rapid weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fatigue, breast tenderness, fluid retention, and digestive discomfort. Through functional testing, targeted supplementation, dietary intervention, and hormone support, Joanne uncovers how gut imbalances were driving systemic inflammation, histamine overload, and estrogen-related symptoms.

You’ll learn how SIBO contributes to nutrient malabsorption, impacts progesterone production, increases histamine activity, and worsens hormone-related symptoms such as acne, mood changes, and menstrual irregularities. Joanne also explains why methane and hydrogen SIBO require different treatment strategies, the importance of bowel motility during gut repair, and how addressing biofilms can improve treatment outcomes.

This episode is ideal for both practitioners and patients seeking deeper insight into the relationship between gut health, histamine intolerance, women’s hormones, PMS, estrogen dominance, acne, fatigue, and digestive dysfunction.