EPISODE # 18

Balancing Methylation: A Game-Changer for Mental Health, Perimenopause & Menopause

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Mood swings, hot flushes, family dynamics and more!

In this episode of The Histamine Well, host Joanne speaks with Amanda Bradshaw, co-founder of Mood Sense, to explore the critical role methylation plays in mood, mental health, and hormonal transitions like perimenopause. Joanne shares her clinical insights and surprising test results showing that some patients assumed to be under-methylators were actually over-methylating—changing the course of their treatment.

Amanda opens up about her personal health journey through perimenopause and how balancing her methylation significantly improved symptoms like mood swings and hot flushes. Together, they unpack how methylation imbalances can impact not just mental health, but also relationships, family dynamics, and even parenting—especially in neurodivergent households.

Listeners will also gain practical guidance on how the Mood Sense test works, and how diet, lifestyle, and targeted supplements can help restore balance and support emotional resilience.

Key Highlights:

  • Amanda’s powerful story of overcoming debilitating perimenopausal symptoms through methylation support
  • Surprising findings of over-methylation in patients previously assumed to be under-methylators
  • The link between methylation patterns and personality traits like competitiveness, anxiety, and emotional overwhelm
  • How methylation imbalances can affect marriage dynamics, communication, and natural boundaries
  • The profound impact of balancing methylation in families, especially with children on the autism spectrum
  • The importance of removing synthetic folic acid in some cases for better mood regulation
  • Why a one-size-fits-all approach to supplementation doesn’t work—and how tailored support changes everything
  • A clear explanation of the Mood Sense test and how to use it for actionable, personalized mental health support

Stay well,

Joanne Kennedy

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