Histamine & Anxiety: Why High Histamine Triggers Stress

EPISODE # 24

Histamine & Anxiety – How High Histamine Triggers Fight-or-Flight Symptoms

Can histamine be the hidden reason behind your anxiety?

In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methylation, estrogen, mold, and gut inflammation (including SIBO and oxalates) all feed into the histamine-anxiety loop.

Whether you’re a practitioner treating patients with anxiety or someone who’s tried everything to feel better — this episode gives you a deeper lens into the hidden biochemical drivers of mental health symptoms.

If you’ve ever felt overstimulated, panicked, or like anxiety hits out of nowhere, you’re going to want to hear this one.

What you’ll learn

How histamine acts as a neurotransmitter in the brain
The difference between over- and under-methylation — and why both can increase brain histamine
Gut-brain histamine signalling (SIBO, H. pylori, oxalates, gluten)
How estrogen, mold, and chronic stress all play into histamine-driven anxiety
Clinical tools and supplements to start reducing your histamine load

Stay well,

Joanne Kennedy

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