EPISODE # 33

Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation

Spotify Podcast Youtube

How estrogen imbalance and COMT dysfunction contribute to over-methylation, mood disorders, and inflammation

In this in-depth episode of the Histamine Well Podcast, Joanne Kennedy unpacks why over-methylation is becoming increasingly common, especially among women. Drawing on clinical observation and biochemistry, Joanne explains how COMT enzyme activity, estrogen dominance, and methyl donor overload can interact to drive symptoms such as anxiety, mood instability, inflammation, sleep disruption, and nervous system overstimulation.

You’ll learn a clear, practical breakdown of the methylation cycle, how estrogen influences COMT and neurotransmitter clearance, and why some patients react poorly to common supplements like methylated B vitamins. Joanne also introduces the Mood Sense test as a real-time tool to assess methylation status, helping practitioners and patients make safer, more individualized decisions.

Featuring insights inspired by James Bradshaw, this episode offers actionable guidance for navigating over-methylation, managing estrogen-related symptoms, and reducing inflammation—without guesswork. Ideal for practitioners, health coaches, and individuals seeking clarity on COMT, estrogen, mood disorders, and inflammatory patterns linked to over-methylation.

What you’ll learn in this episode:

  • Why over-methylation is rising, especially in women
  • How COMT genetics and enzyme activity influence mood and stress tolerance
  • The relationship between estrogen dominance and over-methylation
  • Common signs and symptoms of over-methylation, including anxiety and inflammation
  • Why methylated supplements can worsen symptoms in some individuals
  • How the Mood Sense test can help monitor methylation status in real time
  • Practical considerations for supporting estrogen balance and calming the nervous system
  •  

Stay well,

Joanne Kennedy

Listen, Watch, & Subscribe

Podcast Spotify Youtube

Build A Thriving Practice Transforming People’s Health

Treat dozens of common conditions as a Histamine & Methylation specialist, all without complicated biochemistry or techniques!

LEARN MORE
Ask a Question or Suggest a Topic

Special Offer: Get my Ultimate Histamine Intolerance Bundle

Out Now!
X