In this in-depth episode of The Histamine Well Podcast, I explore why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface. Drawing on clinical observation and biochemistry, I explain how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling and recovery.

You’ll learn a clear, practical breakdown of how inflammation interferes with ovulation and progesterone production, how histamine and estrogen amplify each other in a feedback loop, and why impaired methylation can reduce the body’s ability to detoxify estrogen and regulate neurotransmitters. Joanne also highlights a commonly overlooked issue—over-methylation—and why some individuals experience worsening symptoms when using methylated nutrients such as methyl B12 and methyl folate.

This episode provides a structured framework for understanding why conventional hormone approaches may fall short, and what to consider when addressing deeper biochemical drivers. With a focus on clarity and clinical relevance, Joanne connects the dots between hormone imbalance, histamine intolerance, inflammation, and methylation function.

Ideal for practitioners, health coaches, and individuals seeking a more comprehensive understanding of persistent hormone symptoms, estrogen dominance, and nervous system dysregulation.