In this episode of The Histamine Well Podcast, Joanne explores the emerging connection between histamine, mast cells, hormones, and Premenstrual Dysphoric Disorder (PMDD).

Learn how the estrogen-histamine feedback loop may contribute to mood swings, anxiety, irritability, and other PMDD symptoms, and why some women are finding relief through the use of H1 and H2 antihistamines. Joanne explains the complex relationship between histamine, estrogen, progesterone, neurotransmitters, inflammation, and the menstrual cycle, while also discussing where the current research is strong and where important gaps still exist.

This episode also covers the potential benefits and limitations of H1 and H2 blockers, the role of mast cell activation, and why addressing underlying drivers of histamine excess—including SIBO, mold exposure, oxalates, methylation imbalances, and hormone dysfunction—may be essential for long-term symptom relief.

Whether you’re a practitioner, student, or someone struggling with PMDD, histamine intolerance, MCAS, hormonal imbalances, or severe premenstrual symptoms, this episode provides a deeper understanding of the biological mechanisms that may be contributing to PMDD and how a histamine-focused approach may help.