Methylation Optimisation: What The Biohacking Trend Get Wrong

EPISODE # 51

Methylation Optimisation: What The Biohacking Trend Gets Wrong

The Hidden Risks of Overmethylation and Gene-Based Supplementation

Methylation has become one of the most talked-about topics in functional medicine and biohacking, often promoted as the key to better energy, mood, detoxification, hormone balance, and longevity. But is more methylation always better?

In this episode of The Histamine Well Podcast, Joanne explores the science behind methylation, explains the role of genes such as MTHFR and COMT, and reveals why many people may be taking methylated supplements without understanding their individual biochemistry. Learn the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why gene reports alone may not tell the full story.

Whether you’re a health practitioner, biohacker, or someone interested in methylation, histamine intolerance, hormone health, and functional medicine, this episode provides a balanced, evidence-informed perspective on one of today’s biggest wellness trends.

Key Topics Covered:

What methylation is and why it is essential for human health
The role of methylation in gene expression and epigenetics
How methylation affects neurotransmitters, mood, sleep, and cognition
Methylation’s role in detoxification, hormone metabolism, and cardiovascular health
Why methylation optimization has become a major biohacking trend
Common misconceptions about methylation in functional medicine
Understanding the MTHFR gene and its impact on methylation
The importance of nutrients such as folate, vitamin B12, vitamin B6, and betaine
The difference between undermethylation and overmethylation
How the COMT gene influences methyl group utilization
Signs and symptoms of overmethylation, including anxiety, insomnia, irritability, and racing thoughts
Potential risks of taking methylated supplements without proper assessment
Why genetic reports alone cannot determine methylation status
The limitations of relying solely on SNP testing for treatment decisions
The relationship between estrogen dominance, COMT activity, and methylation balance
Real-world clinical observations on adverse reactions to methylated supplements
Why supporting methylation is not always about increasing methyl groups
The importance of addressing underlying barriers to healthy methylation
Methylation testing options and the value of measuring methylation in real time
A practitioner-focused perspective on personalized methylation support rather than one-size-fits-all protocols

Stay well,

Joanne Kennedy

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