EPISODE # 22

PMDD, Histamine Intolerance & Methylation: Anastasia’s Journey from Breakdown to Breakthrough

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A Real Life Case Study

In this deeply personal and powerful episode, Joanne sits down with patient Anastasia Lamont to explore her journey through PMDD (Premenstrual Dysphoric Disorder), histamine intolerance, and overmethylation. Anastasia opens up about the debilitating symptoms she endured — from suicidal ideation and extreme fatigue to chronic pain and severe skin conditions — and how her life transformed through targeted naturopathic treatment. Together, they unpack the emotional and clinical journey, revealing the role of diet, supplements, and real-time methylation testing in stabilizing mood and reclaiming wellness.

This is a must-listen for anyone living with PMDD or supporting someone who is — and for practitioners looking to understand the powerful intersection between mood, hormones, and histamine.

What We Cover:

  • Anastasia’s struggle with PMDD, endometriosis, ADHD, and histamine intolerance
  • The severe impact of symptoms on her quality of life — including work, relationships, and mental health
  • Why conventional treatments (SSRIs, SNRIs, ADHD meds) failed — and often made things worse
  • How a low-histamine, gluten-free diet helped dramatically reduce pain and inflammation
  • The game-changing role of real-time methylation testing
  • What overmethylation looks like — and how it affects neurotransmitters, mood, and anxiety
  • The surprising link between psychiatric medications and methylation imbalance
  • Key supplements that helped stabilize Anastasia’s methylation and support detox pathways
  • Why inflammation is a root cause of mood disorders and PMDD
  • The clinical value of calcium D-glucarate, Basica, and NAC (Vegenac) in hormonal mood disorders
  • Navigating the social challenges of dietary changes — and why the benefits are worth it

Stay well,

Joanne Kennedy

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